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Updated: 17 min 9 sec ago

Abnormal hyperactivation in the brain may be an early sign of Alzheimer's

Fri, 01/22/2021 - 02:08
A psychology and neuroscience professor has just targeted an early biomarker of the disease.

Deep sleep takes out the trash

Thu, 01/21/2021 - 01:40
By examining fruit flies' brain activity and behavior, the researchers found that deep sleep has an ancient, restorative power to clear waste from the brain. This waste potentially includes toxic proteins that may lead to neurodegenerative disease.

NAD+ can restore age-related muscle deterioration, research finds

Tue, 01/19/2021 - 22:14
Scientists have discovered that Alzheimer's-like protein aggregates underly the muscle deterioration seen in aging. But the aggregates can be reversed by boosting the levels of nicotinamide adenine dinucleotide (NAD+), which turns on the defense systems of mitochondria in cells and restores muscle function.

Eye tests predict Parkinson's-linked cognitive decline 18 months ahead

Tue, 01/19/2021 - 20:58
Simple vision tests can predict which people with Parkinson's disease will develop cognitive impairment and possible dementia 18 months later, according to a new study. In a related study, the researchers also found that structural and functional connections of brain regions become decoupled throughout the entire brain in people with Parkinson's disease, particularly among people with vision problems.

Toadlet peptide transforms into a deadly weapon against bacteria

Fri, 01/15/2021 - 03:08
Researchers have discovered remarkable molecular properties of an antimicrobial peptide from the skin of the Australian toadlet. The discovery could inspire the development of novel synthetic drugs to combat bacterial infections.

Memory may be preserved in condition with brain changes similar to Alzheimer's disease

Thu, 01/14/2021 - 02:42
Primary progressive aphasia is a rare neurodegenerative condition characterized by prominent language problems that worsen over time. About 40% of people with the condition have underlying Alzheimer's disease. But a new study has found that people with the condition may not develop the memory problems associated with Alzheimer's disease.

MIND and Mediterranean diets associated with later onset of Parkinson's disease

Thu, 01/14/2021 - 01:15
A new study suggests a strong correlation between following the MIND and Mediterranean diets and later onset of Parkinson's disease (PD). While researchers have long known of neuroprotective effects of the MIND diet for diseases like Alzheimer's and dementia, this study is the first to suggest a link between this diet and brain health for Parkinson's disease (PD).

Approximately half of AD dementia cases are mild, one-fifth are severe

Wed, 01/13/2021 - 22:37
What percent of patients with Alzheimer's Disease (AD) currently have severe dementia? Do more people have mild disease? Or are the majority suffering with moderate dementia? A new study using data from the Framingham Heart Study (FHS) sheds light on these trends.

New studies support blood test for early detection of Alzheimer's disease

Wed, 01/13/2021 - 20:38
Researchers provide convincing evidence that an in-house developed blood test for Alzheimer's disease can detect the disease early and track its course, which has major implications for a potential use in clinical practice and treatment trials.

Rotten egg gas could guard against Alzheimer's disease

Tue, 01/12/2021 - 21:31
Typically characterized as poisonous, corrosive and smelling of rotten eggs, hydrogen sulfide's reputation may soon get a face-lift thanks to researchers. In experiments in mice, researchers have shown the foul-smelling gas may help protect aging brain cells against Alzheimer's disease.

Including unhealthy foods may diminish positive effects of an otherwise healthy diet

Sun, 01/10/2021 - 01:54
Researchers have reported diminished benefits of a Mediterranean diet among those with high frequency of eating unhealthy foods.

Protein that can be toxic in the heart and nerves may help prevent Alzheimer's

Thu, 01/07/2021 - 23:23
A protein that wreaks havoc in the nerves and heart when it clumps together can prevent the formation of toxic protein clumps associated with Alzheimer's disease, a new study shows. The findings could lead to new treatments for this brain-ravaging condition, which currently has no truly effective therapies and no cure.

Journal article reviews century of data showing COVID-19 likely to impact the brain

Thu, 01/07/2021 - 03:43
Decades of data paint a compelling case for why COVID-19 survivors, even those with few symptoms, could experience long-term effects on the brain and central nervous system.

Solo seniors with cognitive impairment hit hard by pandemic

Thu, 01/07/2021 - 00:00
The pandemic has exacerbated isolation and fears for one very vulnerable group of Americans: the 4.3 million older adults with cognitive impairment who live alone.

A prognostic Alzheimer's disease blood test in the symptom-free stage

Wed, 01/06/2021 - 22:27
Using a blood test, a research team has predicted the risk of Alzheimer's disease in people who were clinically diagnosed as not having Alzheimer's disease but who perceived themselves as cognitively impaired (Subjective Cognitive Declined, SCD). The researchers analyzed blood samples from an SCD cohort. Using a newly developed test, they identified all 22 subjects at study entry who developed Alzheimer's dementia, thus the clinical symptoms, within six years.

Routine eye scans may give clues to cognitive decline in diabetes

Wed, 01/06/2021 - 00:27
As they age, people with diabetes are more likely to develop Alzheimer's disease and other cognitive disorders than are people without diabetes. Scientists now have shown that routine eye imaging can identify changes in the retina that may be associated with cognitive disorders in older people with type 1 diabetes. These results may open up a relatively easy method for early detection of cognitive decline in this population.

New study on circadian clock shows 'junk DNA' plays a key role in regulating rhythms

Tue, 01/05/2021 - 01:29
Researchers have been trying to figure out what regulates molecular circadian clocks, in search of new insights into diseases like Alzheimer's, cancer and diabetes. Until now, that research has focused on what is known as clock genes. But new research reveals the discovery of a new cog in the circadian clock - a genome-wide regulatory layer made up of small chains of non-coding nucleotides known as micro RNAS (miRNAs).

Scientists discover mutations associated with early onset dementia

Tue, 12/22/2020 - 18:42
Scientists have announced a significant advance in our understanding of an early onset form of dementia that may also progress our understanding of conditions such as Alzheimer's disease. Adult onset Leukoencephalopathy with axonal Spheroids and Pigmented glia (ALSP) is an ultra-rare condition that manifests initially with psychiatric and behavioural changes in patients followed by a rapid progression of dementia in the third or fourth decade of life.

Sex-specific Alzheimer's treatment could benefit males over females

Tue, 12/22/2020 - 00:11
A new study found a specific Alzheimer's treatment is effective in male and not female mice, providing a window into the biology of the disease and the effectiveness of targeted treatments.

Driving force behind cellular 'protein factories' identified

Thu, 12/17/2020 - 02:22
Researchers have identified the driving force behind a cellular process linked to neurodegenerative disorders such as Parkinson's and motor neuron disease.