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Read the latest research on Alzheimer's disease. Learn about Alzheimer's symptoms such as memory loss and senile dementia. Find out about Alzheimer's stages, causes and new treatments.
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One-two punch of symptoms that exacerbate Alzheimer's

Fri, 10/16/2020 - 18:31
A new Alzheimer's study found that impaired blood flow in the brain is correlated with the buildup of tau tangles, a hallmark indicator of cognitive decline.The work suggests that treatments targeting vascular health in the brain -- as well as amyloid plaques and tau tangles -- may be more effective in preserving memory.

Could loss of interest be sign of dementia risk?

Thu, 10/15/2020 - 01:35
Older adults with severe apathy, or lack of interest in usual activities, may have a greater chance of developing dementia than people with few symptoms of apathy, according to a new study.

Study underscores the gut-brain connection, shows hunger hormone impacts memory

Tue, 10/13/2020 - 19:46
Rats that lacked the hormone ghrelin tended to eat more frequently and gained more weight. They also showed signs that they could not remember when they had last eaten.

Single gene disorders not so simple after all

Mon, 10/12/2020 - 21:29
Traditionally, geneticists divide disorders into 'simple,' where a single gene mutation causes disease, or complex, where mutations in many genes contribute modest amounts. A new study suggests that the truth is somewhere in between.

Does general anesthesia increase dementia risk?

Wed, 10/07/2020 - 18:26
There are concerns that exposure to general anesthesia during surgery may contribute to an increased risk of Alzheimer's disease. To investigate, researchers compared exposure to general anesthesia versus regional anesthesia during elective surgery, looking for potential links to the development of dementia.

Evidence of Alzheimer's, Parkinson's and MND in brains of young people exposed to dirty air

Wed, 10/07/2020 - 01:05
After examining the brainstems of 186 young Mexico City residents aged between 11 months and 27 years of age, researchers, found markers not only of Alzheimer's disease, but also of Parkinson's and of motor neuron disease (MND) too. These markers of disease were coupled with the presence of tiny, distinctive nanoparticles within the brainstem - their appearance and composition indicating they were likely to come from vehicle pollution.

New tool shows main highways of disease development

Fri, 10/02/2020 - 18:40
A new tool enables researchers to explore disease patterns from 7.2 million patients spanning 25 years. The tool is freely available for the scientific community and requires no prerequisite bioinformatics or medical informatics skills.

Rare genetic form of dementia discovered

Fri, 10/02/2020 - 05:32
A new, rare genetic form of dementia has been discovered by researchers. This discovery also sheds light on a new pathway that leads to protein build up in the brain -- which causes this newly discovered disease, as well as related neurodegenerative diseases like Alzheimer's Disease -- that could be targeted for new therapies.

First 'pathoconnectome' could point toward new treatments for neurodegenerative diseases

Tue, 09/29/2020 - 22:06
Scientists have achieved another first in the field of connectomics, which studies the synaptic connections between neurons. The lab has produced the first pathoconnectome, showing how eye disease alters retinal circuitry.

Epigenetic drivers for Alzheimer's disease uncovered

Tue, 09/29/2020 - 00:59
New findings suggest that late-onset Alzheimer's Disease is driven by epigenetic changes -- how and when certain genes are turned on and off -- in the brain.

Identical signs of brain damage in sleep apnea and Alzheimer's

Mon, 09/28/2020 - 20:04
New research shows damage in the brain starts in the same place and spreads in the same way in sleep apnea, as in Alzheimer's disease. The study is the first to find Alzheimer's-like amyloid plaques in the brains of people with clinically-verified obstructive sleep apnea, a condition that affects more than 936 million people worldwide.

160 genes linked to brain shrinkage in study of 45,000 adults

Sun, 09/27/2020 - 00:21
An analysis conducted in 45,000 adults mainly of European ancestry associated 160 genes with brain shrinkage seen on MRI.

A genetic variant that protects against Alzheimer's disease promotes immune cell functions

Fri, 09/25/2020 - 21:03
A new study has found that the PLCG2-P522R genetic variant, which protects against Alzheimer's disease, enhances several key functions of immune cells. The results obtained in the study highlight the importance of immune cells as a target of future development of new therapies for Alzheimer's disease.

Fructose made in the brain could be a mechanism driving Alzheimer's disease, researchers propose

Wed, 09/23/2020 - 22:18
New research proposes that Alzheimer's disease may be driven by the overactivation of fructose made in the brain. The study outlined the hypothesis that Alzheimer's is a modern disease driven by changes in dietary lifestyle that has resulted in excessive fructose metabolism in the brain.

New mouse model of tau propagation

Wed, 09/23/2020 - 22:16
Accumulation of assembled tau protein in the central nervous system is characteristic of Alzheimer's disease and several other neurodegenerative diseases, called tauopathies. Researchers have now established a new mouse model of tau accumulation and propagation in brain. Single intracerebral injection of synthetic tau filaments induced by dextran sulphate into wild-type mice caused seeding of endogenous tau, followed by spreading to distinct areas in a time-dependent manner.

Sport and memory go hand in hand

Wed, 09/23/2020 - 22:16
If sport is good for the body, it also seems to be good for the brain. By evaluating memory performance following a sport session, neuroscientists demonstrate that an intensive physical exercise session improves memory. How? Through the action of endocanabinoids, molecules known to increase synaptic plasticity. School programs and strategies aimed at reducing the effects of neurodegeneration on memory could benefit from the study.

Amyloid deposits not associated with depression in the elderly

Wed, 09/23/2020 - 22:15
Researchers have suspected that amyloid beta deposits might also underlie the cognitive decline seen in older people with depression, however a new study has found that abnormal amyloid beta deposits were actually found in fewer older adults with major depression compared to non-depressed control subjects.

Biomarker indicating neurodegeneration identified in the eye

Mon, 09/21/2020 - 23:24
A new study indicates a well-known biomarker that serves as a marker for earlier diagnosis of neurodegenerative diseases is now detectable in the eye. Neurofilament light chain, a protein previously detected in cerebrospinal fluid and blood that is being explored as a biomarker to detect neurodegeneration, has now been identified in the vitreous humor, or fluid within the eye.

Higher dementia risk in women with prolonged fertility

Thu, 09/17/2020 - 20:24
Women with a longer reproductive period had an elevated risk for dementia in old age, compared with those who were fertile for a shorter period, a population-based study.

New smart drug delivery system may help treatment for neurological disorders

Thu, 09/17/2020 - 18:10
A research team has created a smart drug delivery system that reduces inflammation in damaged nervous tissues and may help treat spinal cord injuries and other neurological disorders. The system, which uses extremely thin biomaterials implanted in the body, also protects nerve fibers (axons) that connect nerve cells in injured neural tissues, according to a new study.