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Read the latest research on Alzheimer's disease. Learn about Alzheimer's symptoms such as memory loss and senile dementia. Find out about Alzheimer's stages, causes and new treatments.
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Scientists develop new gene therapy for eye disease

Thu, 11/26/2020 - 19:29
Scientists have developed a new gene therapy approach that offers promise for one day treating an eye disease that leads to a progressive loss of vision and affects thousands of people across the globe. The study also has implications for a much wider suite of neurological disorders associated with aging.

Team uses copper to image Alzheimer's aggregates in the brain

Wed, 11/25/2020 - 01:38
A proof-of-concept study conducted in a mouse model of Alzheimer's disease offers new evidence that copper isotopes can be used to detect the amyloid-beta protein deposits that form in the brains of people living with -- or at risk of developing -- Alzheimer's.

Commonly used antibiotic shows promise for combating Zika infections

Wed, 11/25/2020 - 01:38
Researchers used a variety of advanced drug screening techniques to test out more than 10,000 compounds in search of a cure. To their surprise, they found that the widely used antibiotic methacycline was effective at preventing brain infections and reducing neurological problems associated with the virus in mice.

Anxiety associated with faster Alzheimer's disease onset

Tue, 11/24/2020 - 19:51
Anxiety is associated with an increased rate of progression from mild cognitive impairment to Alzheimer's disease, according to a new study.

New connection between Alzheimer's dementia and Dlgap2

Tue, 11/24/2020 - 02:40
A research team has discovered that Dlgap2, a gene that helps facilitate communication between neurons in the nervous system, is associated with the degree of memory loss in mice and risk for Alzheimer's dementia in humans. When studying post-mortem human brain tissue, the researchers also discovered low levels of Dlgap2 in people experiencing 'poorer cognitive health' and 'faster cognitive decline' prior to death.

Early, late stages of degenerative diseases are distinct

Tue, 11/24/2020 - 02:40
Biochemists have proposed that degenerative diseases as varied as Alzheimer's, Parkinson's and muscle atrophy occur in two distinct phases marked by protein signaling changes that could result in patients responding differently to the same treatment.

Eye exam could lead to early Parkinson's disease diagnosis

Mon, 11/23/2020 - 19:23
A simple eye exam combined with powerful artificial intelligence (AI) machine learning technology could provide early detection of Parkinson's disease, according to new research.

Memories create 'fingerprints' that reveal how the brain is organized

Fri, 11/20/2020 - 23:56
While the broad architecture and organization of the human brain is universal, new research shows how the differences between how people reimagine common scenarios can be observed in brain activity and quantified. These unique neurological signatures could ultimately be used to understand, study, and even improve treatment of disorders such as Alzheimer's disease.

Cellular pathway of genetic heart disease similar to neurodegenerative disease

Thu, 11/19/2020 - 09:20
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy.

Does air pollution increase women's risk of dementia?

Thu, 11/19/2020 - 02:41
Older women who live in locations with higher levels of air pollution may have more brain shrinkage, the kind seen in Alzheimer's disease, than women who live in locations with lower levels, according to a new study.

A genetic link to molecular events that precede symptoms in Alzheimer's disease

Thu, 11/19/2020 - 00:48
Researchers find a key mutation causing abnormal transport of BACE1, the enzyme responsible for processing the Alzheimer's disease-linked amyloid protein. Identification of this mutation, which is more common among African Americans with Alzheimer's, may allow early intervention.

Alzheimer's disease drug may help fight against antibiotic resistance

Thu, 11/19/2020 - 00:46
An experimental Alzheimer's disease treatment is proving effective at treating some of the most persistent, life-threatening antibiotic-resistant bacteria. Researchers have discovered that the drug called PBT2 is effective at disrupting and killing a class of bacteria - known as Gram-negative bacteria - that cause infections such as pneumonia, bloodstream infections and meningitis.

Diabetes increases neuritic damage around amyloid plaques in Alzheimer's disease

Wed, 11/18/2020 - 19:59
New research explores the role of diabetes in the cellular and molecular changes underlying Alzheimer's disease (AD).

Does air pollution affect mental health later in life?

Wed, 11/18/2020 - 18:37
In a study of women aged 80 years and older, living in locations with higher exposures to air pollution was associated with increased depressive symptoms.

Retinas: New potential clues in diagnosing, treating Alzheimer's

Wed, 11/18/2020 - 01:15
A study has identified certain regions in the retina - the lining found in the back of the eye - that are more affected by Alzheimer's disease than other areas. The findings may help physicians predict changes in the brain as well as cognitive deterioration, even for patients experiencing the earliest signs of mild impairment.

The long road to dementia

Tue, 11/17/2020 - 22:00
Alzheimer's disease develops over decades. It begins with a fatal chain reaction in which masses of misfolded beta-amyloid proteins are produced that in the end literally flood the brain. Researchers now show that this chain reaction starts much earlier in mice than commonly assumed.

Parasite infection discovery could assist mental health treatments

Mon, 11/16/2020 - 21:59
New research into how a common parasite infection alters human behavior could help development of treatments for schizophrenia and other neurological disorders. T. gondii currently infects 2.5 billion people worldwide and causes the disease Toxoplasmosis.

Overly reactivated star-shaped cells explain the unpredictability of Alzheimer's disease

Mon, 11/16/2020 - 21:58
Researchers have demonstrated that the severity of 'reactive astrocytes' is a key indicator for the onset of Alzheimer's disease.

Link between Alzheimer's disease and gut microbiota is confirmed

Fri, 11/13/2020 - 23:10
In recent years, the scientific community has suspected that the gut microbiota plays a role in the development of the disease. A team now confirms the correlation, in humans, between an imbalance in the gut microbiota and the development of amyloid plaques in the brain, which are at the origin of Alzheimer's disease.

Weekly physical activity may help prevent mild cognitive impairment conversion to dementia

Thu, 11/12/2020 - 21:05
Exercising more than once per week is associated with a lower risk of developing Alzheimer's disease in patients with mild cognitive impairment.